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Terrible night cramps, dry mouth, coldness down to the bone all the time which goes away when I stop taking it. I can breath better with it but it is not worth the other side effects. I have had Bronchitis and asthma since I was 8 yeas old and I am now 70.

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Vandewalker, receiving consulting fees, support to participate in review activities, and travel support and receiving on behalf of his institution a grant from Boehringer Ingelheim connected with this clinical study, receiving grant support from Boehringer Ingelheim, and receiving lecture fees from GlaxoSmithKline, AstraZeneca, and Merck; Drs.

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The population had an age range from 40 to 88 years, was 75% male, 90% Caucasian, and had COPD with a mean pre-bronchodilator FEV 1 percent predicted of 40%.

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The target sample size was met, appropriate measures of COPD improvement were used, and number needed to treat was calculated for 2 of the endpoints.

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